Research Centre Overview

Research Centre Overview

Research Centre

Clinical trials and research studies are a key component of the evidence-based clinical research approach of Beacon Hospital’s Research Centre.

Clinical trials test new treatments in people with cancer, such as: new drugs, new treatment combinations, new approaches to surgery or radiation therapy, or, new methods, such as gene therapy. The goal of this research is to find better ways to treat cancer and help cancer patients.

Clinical trials and research studies are a key component of the evidence-based clinical research approach of Beacon Hospital’s Research Centre.

Clinical trials test new treatments in people with cancer, such as: new drugs, new treatment combinations, new approaches to surgery or radiation therapy, or, new methods, such as gene therapy. The goal of this research is to find better ways to treat cancer and help cancer patients.

If a new treatment proves effective in a study, it may become a new standard treatment that can help many patients. Most of today’s most effective standard treatments are based on previous study results, such as those for breast, colon, rectal, and childhood cancers.

Individuals who participate may be helped personally by the treatment(s) they receive. Trial participants get up-to-date care from cancer experts, and they receive either a new treatment being tested or the best available standard treatment for their cancer.

While there are no guarantees that a new treatment being tested will not carry risks or produce good results, if a new treatment proves effective, or more effective than standard treatment, participants in the clinical trial may be among the first to benefit.

While research studies are of importance in therapeutic advancement, Beacon Hospital’s Research Centre priortises the rights, safety and well-being of patients involved in clinical trials. Apart from the fact that all our clinical studies have secured approval from the Medical and Research Ethics Committee of the Ministry of Health, Malaysia, we also comply with local and international Good Clinical Practice (GCP) standards to safeguard the ethical interests of trial patients.

To date, our oncology team has participated in numerous clinical trials including in comparing the effectiveness of different chemotherapy treatments; resistance to inhibitors; epigenetic changes in nasopharyngeal cancer; and treatment for advanced or metastatic gastroesophageal junction adenocarcinoma, among others.

No Clinical Trial Status
1 MK3475-042:
A Randomized, Open Label, Phase III Study of Overall Survival Comparing Pembrolizumab (MK-3475) versus Platinum Based Chemotherapy in Treatment Naive Subjects with PD-L1 Positive Advanced or Metastatic Non-Small Cell Lung Cancer (Keynote 042)
Active (stop recruiting)
2 EMR200095-006
Phase Ib/II Multicentre, Randomized Open Label Trial to Compare (MSC2156119J) Combined Gefitinib Versus Chemotherapy as Second Line Treatment in Subject with MET (+), Locally Advanced / Metastatic Non-Small Lung Cancer (NSCLC) Harbouring EGFR Mutation and Having Acquired Resistance to Prior EGFR-Tyrosine Kinase Inhibitor
Active (stop recruiting)
3 Tessa FF01:
A Multicentre, Randomised, Open-label, Phase III Clinical Trial of Gemcitabine and Carboplatin followed by Epstein-Barr virus-specific Autologous Cytotoxic T Lymphocytes vs Gemcitabine andCarboplatin as first line treatment for Advanced NPC
Active (recruiting)
4 MK3475-394A
Phase III Randomized Double-Blind study of pembrolizumab plus best supportive care as second-line therapy in Asian subjects with previously systematically treated advanced hepatocellular carcinoma
Active (recruiting)
5 CLEE011A2404
An open-label, multicenter, Phase IIIb study to assess the safety and efficacy of ribocliclib (LEE11) in combination with letrozole for the treatment of men and postmenopausal women with hormone receptor-positive (HR+), HER2-negative (HER2-) advanced breast cancer (ABC) with no prior hormonal therapy for advanced disease
Upcoming (Site Initiation in Aug 2017)
6 Keynote-590A
randomized, double-blind, placebo-controlled phase III clinical trial of pembrolizumab (MK-3475) in combination of cisplatin and 5-fluorouracil versus placebo in combination with cisplatin and 5-fluorouracil as first-line treatment in subjects with advanced/metastatic esophageal carcinoma
Upcoming (CTA/ budget review)
7 CT10-01
Malaysian Cell Therapy Patient Registry: A Patient Registry (clinical database) to Evaluate the Health Outcomes of Patients who had received Cell Therapy In Malaysia
Upcoming (Protocol review)
8 Studies On Epigenetic Changes In Nasopharyngeal Cancer Completed
9 Healthcare Performance Measurement And Reporting System (HPMRS) For Cancer Care Completed
10 Healthcare Performance Measurement And Reporting For Breast Cancer Services In Malaysia Completed (View abstract) (View paper)
11 A Randomized, Phase II, Placebo Controlled Study Of Lacebo Controlled Study Of GDC-0068, An Inhibitor To AKT, In Combination With Fluoropyrimidine Plus Oxaliplatin In Patients With Locally Advanced Or Metastatic Gastric Or Gastroesophageal Junction Adenocarcinoma Completed
12 A Randomized, 3 Arm, Multicentre, Phase III Study To Evaluate Completed
13 A Multiple Center, Open-Label, Randomized Phase III Study To Evaluate The Efficacy And Safety Of Erlotinib (Tarceva®) Versus Gemcitabine / Cisplatin As The First-Line Treatment For Stage IIIB / IV Non-Small Cell Lung Cancer (NSCLC) Patients With Mutations In The Tyrosine Kinase Domain Of Epidermal Growth Factor Receptor (EGFR) In Their Tumors. Completed
14 An Open-Label, Randomized Phase 3 Study Of The Efficacy And Tolerability Of Linifanib (ABT-869) Versus Sorafenib In Subjects With Advanced Hepatocellular Carcinoma (HCC) Completed

Apart from oncology clinical trials, our consultants from other centres of excellence have also made substantial contributions to their clinical specialty with their published research. Below are the research publications (abstract, research papers, poster presentations, etc) produced by our consultants:

No Publication Title Name of Consultant Type of Presentation
1 Does A Picture Really Paint A Thousand Words? A Study On The Technical Qualities Of Online Aesthetic Oculofacial Clinical Photographs Dr Ong Chin Tuan
(Consultant Ophthalmologist)
Poster

If you are interested and want to know more about these ongoing trials, please contact us at +603 7620 7979 ext 2854 or you can drop us an email at info@beaconhospital.com.my 

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