Studi penelitian dan uji coba klinis adalah komponen kunci dari pendekatan penelitian klinis berdasarkan bukti dari pusat penelitian Beacon Hospital.
Tes uji coba klinis memperbarui pengobatan pasien penderita kanker, seperti: obat baru, kombinasi pengobatan baru, pendekatan baru pembedahan atau terapi radiasi, atau metode baru, seperti terapi gen. Tujuan penelitian ini adalah untuk menemukan cara yang lebih baik dalam mengobati kanker dan menolong pasien kanker.
Jika pengobatan baru efektif dalam sebuah studi, ia dapat dijadikan pengobatan standar yang dapat menolong banyak pasien. Umumnya pengobatan standar yang paling efektif sekarang ini berdasarkan pada hasil studi sebelumnya, seperti pada kanker payudara, kolon, rektal dan kanker yang menyerang pada anak-anak.
Pasien yang berpartisipasi dapat terbantu dengan sendirinya melalui pengobatan yang mereka terima. Peserta uji coba mendapatkan pengobatan terbaru dari spesialis kanker dan mereka memperoleh baik pengobatan baru yang telah diuji atau pengobatan standar terbaik yang tersedia untuk kanker yang diderita.
Tidak terdapat jaminan bahwa pengobatan baru yang telah diuji coba tidak akan menimbulkan efek samping ataupun akan memberikan hasil yang baik. Jika pengobatan baru terbukti efektif atau lebih efektif daripada pengobatan standar, peserta uji coba klinis inilah yang pertama merasakan manfaatnya.
Meskipun studi penelitian sangat penting bagi kemajuan pengobatan, pusat penelitian Beacon Hospital mengutamakan hak, keamanan dan kesejahteraan pasien yang terlibat dalam uji coba klinis. Terlepas dari kenyataan bahwa semua studi klinis kami telah mendapatkan persetujuan dari komite etika medis dan penelitian Kementerian Kesehatan Malaysia, kami juga mematuhi standar praktik klinis local atau internasional yang baik untuk menjaga kepentingan etis pasien uji coba klinis.
Hingga kini, tim onkologi kami telah berpartisipasi dalam berbagai uji coba klinis termasuk membandingkan efektivitas pengobatan kemoterapi yang berbeda; resistansi penghambat; perubahan epigenetik pada kanker nasofaring; dan pengobatan untuk adenocarcinoma pada persimpangan gastroesofagus stadium lanjut atau metastatik.
| No. | Clinical Trial | Status |
|---|---|---|
| 1 | ML41262 A Prospective, Multicentre, Genomic Profiling Study In Patients With Locally Advanced Or Metastatic Non-small Cell Lung Cancer (NSCLC) In Malaysia Using Foundation Medicine |
Active (Recruiting) |
| 2 | PFIZER A7471067 Real-world utilization and outcomes with “study drug” first-line treatment for EGFR mutation-positive advanced non-small cell lung cancer among Asian patients – A multi-center chart review |
Active (Recruiting) |
| 3 | MK7684A-002 A Phase 2, Multi-Center, Randomised study to compare the efficacy and safety of MK-7684-A or MK-7684-A Plus Docetaxel versus Docetaxel Monotherapy in the treatment of particpants with Metastatic NSCLC with progressive disease after treatment with a Platinum Doublet Chemo or Immunotherapy |
Active (Recruiting) |
| 4 | MO42541- IMBRAVE251 A Phase III, Open-Label, Randomised Study of ATEZOLIZUMAB WITH LENVATINIB OR SORAFENIB VERSUS LENVATINIB OR SORAFENIB Alone in Hepatocellular carcinoma previously treated with atezolizumab and bevacizumab |
Active (Recruiting) |
| 5 | MARIPOSA2 A phase 3, Open-Label, Randomised Study of Amivantamab and Lazertinib in Combination with Platinum-Based Chemotherapy Compared with Platinum-Based Chemotherapy in Patients with EGFR-Mutated Advanced or Metastatic NSCLC After Osimertinib Failure |
Active (Recruiting) |
| 6 | Pacific 8 A Phase 3, Randomised, Double blind, Placebo controlled, Multicentre, International Study of Durvalumab plus Domvanalimab (AB154) in Participants with Locally Advanced (Stage III), Unresectable Non small Cell Lung Cancer Whose Disease has not Progressed Following Definitive Platinum based Concurrent Chemoradiation Therapy |
Active (Recruiting) |
| 7 | Adaura 2 A Phase III, Double-blind, Randomised, Placebo-Controlled, International Study to assess the Efficacy and Safety of Adjuvant Osimertinib versus Placebo in Participants with EGFR mutation-positive Stage IA2-IA3 Non-small Cell Lung Cancer, following Complete Tumour Resection |
Active (Recruiting) |
| 8 | InCyte Podium (INCMGA0012-304) A Randomized, Double Blind, Phase 3 Study of Platinum-based Chemotherapy with or without INCMGA00012 in First-Line Metastatic Squamous and Nonsquamous Non-Small Cell Lung Cancer Participants (POD1UM 304) |
Active (Recruiting) |
| 9 | MARIPOSA A Randomized Study of JNJ-61186372 and Lazertinib Combination Therapy Versus Single Agent Osimertinib or Lazertinib as First-Line Treatment in Patients with EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer. |
Active (Recruiting) |
| 10 | MS200095-0031-INSIGHT 2 A Phase II, two-arm study to investigate tepotinib combined with osimertinib in MET amplified, advanced or metastatic non-small cell lung cancer (NSCLC) harboring activating EGFR mutations and having acquired resistance to prior Osimertinib therapy. |
Active (Recruiting) |
| 11 | KontRASt-02 Study of JDQ443 in Comparison with Docetaxel in Participants with Locally Advanced or Metastatic KRAS G12C Mutant Non-small Cell Lung Cancer |
Active (Recruiting) |
| 12 | PALOMA 3 A Phase 3, Open-label, Randomized Study of Lazertinib with Subcutaneous Amivantamab Administered via Manual Injection Compared with Intravenous Amivantamab or Amivantamab Subcutaneous On Body Delivery System in Patients with EGFR-mutated Advanced or Metastatic Non-small Cell Lung Cancer After Progression on Osimertinib and Chemotherapy |
Active (Recruiting) |
| 13 | EPIK-B2 A two part, Phase III, multicenter, randomized (1:1), double-blind, placebo-controlled study to assess the efficacy and safety of alpelisib (BYL719) in combination with trastuzumab and pertuzumab as maintenance therapy in patients with HER2-positive advanced breast cancer with a PIK3CA mutation |
Active (Recruiting) |
| 14 | Lidera A Phase III, Randomized, Open-Label, Multicenter Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared with Physician’s Choice of Adjuvant Endocrine Monotherapy in Patients with Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer |
Active (Recruiting) |
| 15 | Krystal 10 Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation |
Active (Recruiting) |
| 16 | Origami -1 A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer |
Active (Recruiting) |
| 17 | ATORG003 A single-arm, open-label, phase 2 study of dacomitinib with or without dose titration for the first-line treatment of locally advanced or metastatic non-small cell lung cancer in subjects with an epidermal growth factor receptor (egfr) activation mutation |
Active (Recruiting) |
| 18 | LAURA A Phase III, randomized, double-blind, placebo-controlled, multicenter, international study of osimertinib as maintenance therapy in patients with locally advanced, unresectable EGFR mutation-positive on-Small Cell Lung Cancer (Stage III) whose disease has not progressed following definitive platinum-based chemoradiation therapy (LAURA). |
Active (Recruiting) |
| 19 | Invitrocue PDO for drug screening Validating the use of patient-derived organoids for predicting drug response to chemotherapy in patients with advanced solid cancers |
Active (Recruiting) |
| 20 | CBYL719H12301 – EPIK B3 A Phase III, multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of alpelisib (BYL719) in combination with nab-paclitaxel in patients with advanced triple negative breast cancer with either phosphoinositide-3-kinase catalytic subunit alpha (PIK3CA) mutation or phosphatase and tensin homolog protein (PTEN) loss without PIK3CA mutation. |
Active (Recruiting) |
| 21 | ATORG 001 A prospective, molecular profiling study of mutational genes in Asian patients with Non-Small Cell Lung Cancer. (Non-interventional study). |
Active (Recruiting) |
| 22 | ATORG004 Plasma Molecular Profiling in ALK inhibitor resistant non-small cell lung cancer (Investigator Initiated Research) |
Active (Recruiting) |
| 23 | CT-P16 3.1 A double-blind, randomized, active-controlled, parallel-Group, Phase 3 study to compare efficacy and safety of CT-P16 and EU-approved Avastin as first-line treatment for metastatic or recurrent non-squamous non-small cell lung cancer. |
Active (Stop Recruiting) |
| 24 | MK7902-007 A Phase III, randomized, double-blind trial of Pembrolizumab (MK-3475) with or without lenvatinib (E7080/MK-7902) in participants with treatment-naïve, metastatic non-small cell lung cancer (NSCLC) whose tumors have a tumor proportion score (TPS) greater than or equal to 1% (LEAP-007). |
Active (Stop Recruiting) |
| 25 | MK3475-394 A Phase III Randomized Double-Blind study of pembrolizumab plus best supportive care as second-line therapy in Asian subjects with previously systematically treated advanced hepatocellular carcinoma |
Active (Stop Recruiting) |
| 26 | MK3475-042: A Randomized, Open Label, Phase III Study of Overall Survival Comparing Pembrolizumab (MK-3475) versus Platinum Based Chemotherapy in Treatment Naive Subjects with PD-L1 Positive Advanced or Metastatic Non-Small Cell Lung Cancer (Keynote 042) |
Active (Stop Recruiting) |
| 27 | BTM ASEAN Bone turnover markers reference database in five South East Asia Countries |
Completed |
| 28 | Keynote-590 A randomized, double-blind, placebo-controlled phase III clinical trial of pembrolizumab (MK-3475) in combination of cisplatin and 5FU versus placebo in combination with cisplatin and 5FU as first-line treatment in subjects with advanced/metastatic esophageal carcinoma |
Completed |
| 29 | EMR200095-006 Phase Ib/II Multicentre, Randomized Open Label Trial to Compare (MSC2156119J) Combined Gefitinib Versus Chemotherapy as Second Line Treatment in Subject with MET (+), Locally Advanced / Metastatic Non-Small Lung Cancer (NSCLC) Harbouring EGFR Mutation and Having Acquired Resistance to Prior EGFR-Tyrosine Kinase Inhibitor |
Completed |
| 30 | Tessa FF01: A Multicentre, Randomised, Open-label, Phase III Clinical Trial of Gemcitabine and Carboplatin followed by Epstein-Barr virus-specific Autologous Cytotoxic T Lymphocytes vs Gemcitabine andCarboplatin as first line treatment for Advanced NPC |
Completed |
| 31 | Hyperthermia – REMISSION 1C Hyperthermia in Treating Patients with Unresectable Abdominal, Pelvic tumours and Cutaneous and Peritoneal Metastases |
Completed |
| 32 | TROIKA A randomised, double-blind, parallel group, equivalence, multicentre phase III trial to compare the efficacy, safety, and pharmacokinetics of HD201 to Herceptin® in patients with HER2+ early breast cancer |
Completed |
| 33 | CLEE011A2404 An open-label, multicenter, Phase IIIb study to assess the safety and efficacy of ribocliclib (LEE11) in combination with letrozole for the treatment of men and postmenopausal women with hormone receptor-positive (HR+), HER2-negative (HER2-) advanced breast cancer (ABC) with no prior hormonal therapy for advanced disease |
Completed |
| 34 | Studies On Epigenetic Changes In Nasopharyngeal Cancer | Completed |
| 35 | Healthcare Performance Measurement And Reporting System (HPMRS) For Cancer Care | Completed |
| 36 | Healthcare Performance Measurement And Reporting For Breast Cancer Services In Malaysia | Completed (View Abstract) (View Paper) |
| 37 | A Randomized, Phase II, Placebo Controlled Study Of Lacebo Controlled Study Of GDC-0068, An Inhibitor To AKT, In Combination With Fluoropyrimidine Plus Oxaliplatin In Patients With Locally Advanced Or Metastatic Gastric Or Gastroesophageal Junction Adenocarcinoma | Completed |
| 38 | A Multiple Center, Open-Label, Randomized Phase III Study To Evaluate The Efficacy And Safety Of Erlotinib (Tarceva®) Versus Gemcitabine / Cisplatin As The First-Line Treatment For Stage IIIB / IV Non-Small Cell Lung Cancer (NSCLC) Patients With Mutations In The Tyrosine Kinase Domain Of Epidermal Growth Factor Receptor (EGFR) In Their Tumors. | Completed |
| 39 | An Open-Label, Randomized Phase 3 Study Of The Efficacy And Tolerability Of Linifanib (ABT-869) Versus Sorafenib In Subjects With Advanced Hepatocellular Carcinoma (HCC) | Completed |
Terlepas dari uji coba klinis onkologi, konsultan kami dari pusat-pusat keunggulan lainnya juga memberikan kontribusi pada spesialisasi klinis mereka dengan penelitian mereka yang dipublikasikan.
|
No. |
Publication Title |
Name of Consultant |
Type of Presentation |
|
1 |
Healthcare Performance Measurement And Reporting System (HPMRS) For Cancer Care |
|
|
|
2 |
Healthcare Performance Measurement And Reporting For Breast Cancer Services in Malaysia |
|
|
|
3 |
Does A Picture Really Paint A Thousand Words? A Study On The Technical Qualities Of Online Aesthetic Oculofacial Clinical Photographs |
Dr Ong Chin Tuan |
|
|
4 |
Breast cancer survivorship in an Asian specialist centre from Malaysia: A retrospective analysis |
Dato Ibrahim |
|
|
5 |
Presenting complaints of patients and palliative care referral patterns |
Dr Felicia Chang |
|
|
6 |
KASRP |
Dr Koon Sim Lan |
|
Jika anda tertarik dan ingin mengetahui lebih lanjut mengenai uji coba klinis yang sedang berlangsung, silahkan hubungi kami di +603 7787 2854 atau anda dapat mengirim email pada kami di clinicalresearch@beaconhospital.com.my.
© 2023 Beacon Hospital Sdn Bhd. All Rights Reserved. (KKLIU 3120/2021)
