Cyclotron-Imaging-Service-Beacon-Hospital-Malaysia

What Is Cyclotron?

Cyclotron is a device used to accelerate particles that constantly shoots a beam of charged protons in a circular direction that creates radioisotopes for a group of drugs known as radiopharmaceuticals, which are used to detect and treat cancer. Charged particles are propelled to extremely high speeds and energy using electromagnetic fields. These protons are used to bombard stable isotopes, which are non-radioactive materials, to create medical radioisotopes. A nuclear reaction happens when the proton beam interacts with the stable isotopes, turning them into radioactive isotopes (radioisotopes).

The cyclotron is a vital resource for both innovation and medical treatment. It will enable us to diagnose many illnesses accurately and early. With its rapid advancements in recent years, Positron Emission Tomography (PET) is quickly becoming a vital imaging tool for cancer patient evaluation and staging.

The on-demand availability of radiotracers, or radiopharmaceuticals, tagged with appropriate positron emitting radioisotopes is essential to the smooth operation of a PET facility. PET can be used individually or in combination with other imaging modalities that primarily use anatomical definitions of disease, such as radiography, computed tomography (CT), or magnetic resonance imaging (MRI).

The most effective and often used imaging agent in PET nowadays is 2-[18F]-fluoro-2-deoxy-D- glucose (FDG), one of hundreds of positron-labelled radiotracers. The foundation of FDG’s remarkable success is the novel idea of “metabolic trapping,” which involves the use of a radiotracer to enable direct in vivo monitoring of metabolic processes.

FDG is widely used in oncology to treat cancer patients. FDG-enhanced whole body PET imaging improves cancer detection and staging, therapy selection, and therapeutic response evaluation by measuring glucose metabolism in all organ systems with a single scan. Cancer is a widespread illness, with metastases causing the most severe effects, even if it starts in a single organ. FDG-PET has proven useful in the diagnosis, staging, and restaging of various clinical conditions because it frequently enables the early detection and evaluation of metastasis. Clinical conditions include:

Lung Cancer

Colorectal Cancer

Lymphoma

Melanoma

Head and neck cancer

Oesophageal cancer

Beacon Hospital houses the SIEMENS RDS Eclipse Cyclotron, which is a sophisticated piece of equipment that is used to produce a fresh radiotracer known as 18F-FDG (Fluorodeoxyglucose) daily. Due to their short half-life, these drugs must be injected within minutes of production. The cyclotron facility in Beacon is a GMP (Good Manufacturing Practice) certified facility by NPRA (National Pharmaceutical Bureau Agency, Malaysia) and therefore is licensed to supply FDG nationwide. Currently Beacon Hospital actively supplies FDG to various private & government hospitals across Malaysia.

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